NIH has created the NIH StrokeNet to conduct small and large clinical trials and research studies to advance acute stroke treatment, stroke prevention, and recovery and rehabilitation following a stroke across the lifespan. This network of 27 regional centers across the U.S., which involves approximately 500 hospitals in the U.S., is designed to serve as the infrastructure and pipeline for exciting new potential treatments for patients with stroke and those at risk for stroke. The StrokeNet trials also collaborate with sites in other countries including Canada, Germany, United Kingdom, Spain, and Japan. In addition, NIH StrokeNet will provide an educational platform for stroke physicians, clinical trial coordinators and stroke researchers.
NINDS established the NIH StrokeNet to facilitate the development, promotion and conduct of high-quality, multi-site clinical trials focused on key interventions in stroke prevention, treatment and recovery. An additional goal of the StrokeNet is to educate future stroke investigators and researchers in stroke prevention, treatment and recovery. The educational core provides webinars focused on stroke, research methodology and professional development. This network currently has a network of 27 regional coordinating centers, involves approximately 500 hospitals across the United States and is designed to serve as the infrastructure and pipeline for new potential treatments for patients with stroke and those at risk of stroke.
Exciting news! The 5th WSO-GAINS-ESO Early Career Investigators Workshop will be held at the World Stroke Congress on October 22, 2025 from 1-4:30pm. The goal of the workshop is to connect early career investigators in stroke with each other, and also with experienced mentors from across the globe. Designed for early-career researchers across all disciplines, this workshop offers an invaluable chance to receive feedback on research, discuss challenges, and network with peers and mentors. Key topics include research career development, trial design, grant writing, and more – agenda attached. There is a clear need for young stroke researchers to build their networks and get support. With our partners, the WSO hopes to continue to grow the next generation of researchers in stroke. Full story
The Neuro-EM is a national EM training program of relevance to StrokeNet because it supports EM physicians in their first or second year of a faculty appointment (after residency or fellowship) and funds their research and career development for up 3 years. There is also a Pipeline Program that provides networking opportunities and grant writing training to EM senior residents, fellows, and first year faculty before they apply to be a scholar in future years. The 2025 scholar applications are due Oct 1 (LOIs due Sept 3), and Pipeline Program nominations are due October 1. You can also find our program on Bluesky, Instagram, and LinkedIn. Full story
These findings were recently published in the journal Stroke by lead author Iris Davis (University of Cincinnati, Cincinnati, USA), corresponding author Christopher Streib (University of Minnesota, Minneapolis, USA), and colleagues. Click Full Story Full story
National Clinical Trials Day is observed on May 20 every year to mark the anniversary of the day in 1747 when James Lind conducted the first randomized clinical study. Today we take a moment to recognize the accomplishments of all the clinical research professionals involved in NIH StrokeNet, in public health, and in medicine by recognizing their efforts in clinical trials. It is also a day to express gratitude to clinical research experts for their contributions to the advancement of public health through their work. The goal is to make this a primary focus for international communication activities, meetings, discussions, and celebrations of clinical research over this period as well. We are extremely grateful for our thousands upon thousands of patients and StrokeNet participants who without their engagement this work would not be possible. And we thank you for your contribution, however great or small – You are StrokeNet. Full story
The Clinical Trials Methodology Course invites you to join the spring 2025 webinar series. These lectures cover topics on clinical trial development and occur on Fridays at noon EST and are available for streaming if that time doesn't work for you. All can listen in on this public resource. More information:https://www.ninds-ctmc.org/webinars-resources Full story
Steven M. Greenberg, Wendy C. Ziai, Charlotte Cordonnier, Dar Dowlatshahi, Brandon Francis, Joshua N. Goldstein, J. Claude Hemphill III, Ronda Johnson, Kiffon M. Keigher, William J. Mack, J. Mocco, Eileena J. Newton, Ilana M. Ruff, Lauren H. Sansing, Sam Schulman, Magdy H. Selim, Kevin N. Sheth, Nikola Sprigg, Katharina S. Sunnerhagen, and on behalf of the American Heart Association/American Stroke Association, Published May 17, 2022 Full story
Ashkan Shoamanesh, Magdy Selim, Published June 6, 2022 Full story
Kevin N. Sheth, MD, Magdy Selim, MD, PhD, Published June 27, 2022 Full story
The primary concern for StrokeNet is the safety of our patients or potential patients for our ongoing trials. The second concern is the safety of our own investigators and study team members. Finally, we also want to maintain, as much as possible, the integrity of the trials to potentially benefit patients and so that the data can be used to answer the questions that the trials intended. This latter point is critical for subjects in the trial and those with the specific problem in the future. However, immediate safety issues take priority over any formal processes in ongoing trials. For example, while a current protocol may specify that a study visit needs to be in person, the FDA has guidance about the primary safety of study subjects: For more information click Full Story: Full story
The National Institute of Neurological Disorders and Stroke (NINDS), and National Institutes of Health (NIH) recently assembled an external working group of international experts to update the Stroke v1.0 Common Data Elements (CDEs) based on user feedback and research advances. Full story
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Despite the advances made in acute stroke care, stroke remains the leading cause of adult disability in Americans. World-wide there is an estimated 50 million stroke survivors coping with significant physical, cognitive and emotional deficits. The field of stroke recovery and restorative neuroscience is still young and provides a rich environment for innovative trials. .
NIH StrokeNet Education “Pathophysiological Links between Migraine and Stroke”; Presented by Cenk Ayata, MD, Harvard Medical School, Massachusetts General Hospital NIH StrokeNet Education “Pathophysiological Links between Migraine and Stroke”; Presented by Cenk Ayata, MD, Harvard Medical School, Massachusetts General HospitalNIH StrokeNet Education “Pathophysiological Links between Migraine and Stroke.
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