The Cincinnati team includes over 50 collaborators, including internationally renowned clinical trialists, study coordinators, and scientists, with complementary skill sets in theory, design, and “real-world” issues regarding acute treatment, stroke prevention, and recovery. We have clinically coordinated numerous NIH multicenter national and international clinical trials (ex: IMS I, IMS II, IMS III, CLEAR, CLEAR-ER, STOP IT) and observational studies (GERFHS, GCNKSS, ERICH). We have consistently been a leading enroller in trials since the pilot NINDS rtPA studies in the 1980’s to more recent trials such as IRIS (#3), IMS III (#1), CLEAR-ER (#1), ALIAS (#8), and the ongoing POINT (#3). We have over 30 research coordinators with over 200 years of collective experience. The multiple PIs, Dr. Khatri (lead) and Dr. Kleindorfer, will bring their own well-recognized clinical trial expertise and leadership to facilitate this highly accomplished group’s involvement in the NSTN.