The purpose of this funding opportunity announcement (FOA) issued by NINDS is to invite applications for network sites for the NIH Stroke Preclinical Assessment Network (SPAN). SPAN will facilitate testing of up to 6 promising neuroprotective drugs or interventions to be given prior to or at the time of reperfusion in experimental models of ischemic stroke (e.g., transient middle cerebral artery occlusion). The awarded network sites will become part of the network and will collaborate with the other awarded sites under the oversight and central coordination provided by the SPAN Coordinating Center (RFA-NS-18-034).
Applicants for the network sites must propose a promising neuroprotective intervention to be tested within SPAN; awarded sites will test up to 6 interventions in parallel, including their own. If successful, this network will accelerate the identification of the most promising neuroprotective therapies for future pivotal clinical trials and span the gap between preclinical and clinical testing, in a cost-and time-effective fashion. https://grants.nih.gov/grants/guide/rfa-files/RFA-NS-18-033.html